Cell atlas - TUBB3 - The Human Protein Atlas

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TUBB3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	TUBB3
Gene description	Tubulin, beta 3 class III
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA043640
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Microtubules (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043640	A-431	Microtubules
	HPA043640	U-2 OS	Microtubules
	HPA043640	U-251 MG	Microtubules

GENE INFORMATION
Gene name	TUBB3 (HGNC Symbol)
Synonyms	beta-4, CFEOM3, CFEOM3A, FEOM3
Description	Tubulin, beta 3 class III (HGNC Symbol)
Entrez gene summary	This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89921392 - 89938761
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258947 (version 83.38)
Entrez gene	10381
UniProt	Q13509 (UniProt - Evidence at protein level)
neXtProt	NX_Q13509
Antibodypedia	TUBB3 antibodies

PROTEIN BROWSER

TUBB3-001	TUBB3-002	TUBB3-003	TUBB3-004	TUBB3-005	TUBB3-010	TUBB3-011	TUBB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUBB3-001 ENSP00000320295 ENST00000315491	Q13509 [Direct mapping] Tubulin beta-3 chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007017 [microtubule-based process] GO:0007067 [mitotic nuclear division] GO:0007411 [axon guidance] GO:0015630 [microtubule cytoskeleton] GO:0030182 [neuron differentiation] GO:0030424 [axon] GO:0030425 [dendrite] GO:0042277 [peptide binding] GO:0043025 [neuronal cell body] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] GO:0070062 [extracellular exosome] GO:0071944 [cell periphery] Show all	450 aa 50.4 kDa	No	0
TUBB3-002 ENSP00000451617 ENST00000554444	Q13509 [Direct mapping] Tubulin beta-3 chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007017 [microtubule-based process] GO:0007411 [axon guidance] GO:0030425 [dendrite] GO:0043234 [protein complex] GO:0044267 [cellular protein metabolic process] GO:0051084 ['de novo' posttranslational protein folding] GO:0051258 [protein polymerization] GO:0070062 [extracellular exosome] Show all	378 aa 42.4 kDa	No	0
TUBB3-003 ENSP00000452166 ENST00000556565	G3V542 [Direct mapping] Tubulin beta-3 chain Show all	Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	46 aa 5 kDa	No	0
TUBB3-004 ENSP00000450538 ENST00000555810	G3V2A3 [Direct mapping] Tubulin beta-3 chain Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	189 aa 20.7 kDa	No	0
TUBB3-005 ENSP00000452554 ENST00000555576	G3V5W4 [Direct mapping] Tubulin beta-3 chain Show all	Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	97 aa 10.8 kDa	No	0
TUBB3-010 ENSP00000450822 ENST00000554336	G3V2R8 [Direct mapping] HCG1983504, isoform CRA_e; Tubulin beta-3 chain Show all	Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	118 aa 13.6 kDa	No	0
TUBB3-011 ENSP00000450765 ENST00000553967	G3V2N6 [Direct mapping] HCG1983504, isoform CRA_d; Tubulin beta-3 chain Show all	Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	164 aa 18.3 kDa	No	0
TUBB3-201 ENSP00000485859 ENST00000625617	G3V3R4 [Direct mapping] HCG1983504, isoform CRA_c; Tubulin beta-3 chain Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003924 [GTPase activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005525 [GTP binding] GO:0005874 [microtubule] GO:0007017 [microtubule-based process] GO:0008152 [metabolic process] Show all	148 aa 16.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.