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Gene name

Class

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Chromosome

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Method

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Searches

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GH1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GH1

Gene description

Growth hormone 1

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enriched (pituitary gland)
FANTOM5:Group enriched (pituitary gland, placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in cells in anterior pituitary gland and placenta.

DATA RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. Antibody staining mainly consistent with external characterization data and GTEx RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA043715
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Pituitary gland
N/A
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Pituitary gland

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Pituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0246810TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin010,00020,00030,00040,00050,000RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, placenta)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina01,0002,0003,0004,0005,0006,0007,000Tags Per Million

GENE INFORMATION

Gene name

GH1 (HGNC Symbol)

Synonyms

GH, GH-N, GHN, hGH-N

Description

Growth hormone 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q23.3

Chromosome location (bp)

63917200 - 63918838

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000259384 (version 83.38)

Entrez gene

2688

UniProt

P01241 (UniProt - Evidence at protein level)

neXtProt

NX_P01241

Antibodypedia

GH1 antibodies

PROTEIN BROWSER

GH1-001
GH1-003
GH1-004
GH1-201
GH1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GH1-001
ENSP00000312673
ENST00000323322
P01241 [Direct mapping]
Somatotropin
B1A4G6 [Target identity:100%; Query identity:100%]
Growth hormone 1 isoform 1; HCG1749481, isoform CRA_s
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Show all
GO:0005131 [growth hormone receptor binding]
GO:0005148 [prolactin receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007259 [JAK-STAT cascade]
GO:0008083 [growth factor activity]
GO:0010535 [positive regulation of activation of JAK2 kinase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015758 [glucose transport]
GO:0032355 [response to estradiol]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046872 [metal ion binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070977 [bone maturation]
Show all
217 aa
24.8 kDa
Yes 0
GH1-003
ENSP00000408486
ENST00000458650
P01241 [Direct mapping]
Somatotropin
B1A4G7 [Target identity:100%; Query identity:100%]
Growth hormone 1 isoform 2; HCG1749481, isoform CRA_aa
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Show all
GO:0005131 [growth hormone receptor binding]
GO:0005148 [prolactin receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007259 [JAK-STAT cascade]
GO:0008083 [growth factor activity]
GO:0010535 [positive regulation of activation of JAK2 kinase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015758 [glucose transport]
GO:0032355 [response to estradiol]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046872 [metal ion binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070977 [bone maturation]
Show all
202 aa
23 kDa
Yes 0
GH1-004
ENSP00000343791
ENST00000351388
P01241 [Direct mapping]
Somatotropin
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Show all
GO:0005131 [growth hormone receptor binding]
GO:0005148 [prolactin receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0007259 [JAK-STAT cascade]
GO:0008083 [growth factor activity]
GO:0010535 [positive regulation of activation of JAK2 kinase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0015758 [glucose transport]
GO:0032355 [response to estradiol]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046872 [metal ion binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070977 [bone maturation]
Show all
177 aa
20.2 kDa
Yes 0
GH1-201
ENSP00000339278
ENST00000342364
B1A4G9 [Direct mapping]
Growth hormone 1 isoform 4; HCG1749481, isoform CRA_g; Somatotropin
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
Show all
122 aa
14 kDa
Yes 0
GH1-202
ENSP00000481276
ENST00000617086
B1A4H0 [Direct mapping]
Growth hormone 1 isoform 5; Somatotropin
Show all
Predicted intracellular proteins
Show all
30 aa
3.5 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.