Expression of MRPL46 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L46

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA050166

GENE INFORMATION
Gene name	MRPL46 (HGNC Symbol)
Synonyms	C15orf4, LIECG2, P2ECSL
Description	Mitochondrial ribosomal protein L46 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q25.3
Chromosome location (bp)	88459476 - 88467419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000259494 (version 83.38)
Entrez gene	26589
UniProt	Q9H2W6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2W6
Antibodypedia	MRPL46 antibodies

PROTEIN BROWSER

MRPL46-001	MRPL46-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL46-001 ENSP00000312311 ENST00000312475	Q9H2W6 [Direct mapping] 39S ribosomal protein L46, mitochondrial Show all	Ribosomal proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003735 [structural constituent of ribosome] GO:0005575 [cellular_component] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0016787 [hydrolase activity] GO:0030054 [cell junction] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	279 aa 31.7 kDa	No	0
MRPL46-005 ENSP00000477676 ENST00000558531	A0A087WT90 [Direct mapping] 39S ribosomal protein L46, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005762 [mitochondrial large ribosomal subunit] Show all	169 aa 19.1 kDa	No	0