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HOXB7

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GENERAL INFORMATION

Gene name

 HOXB7

Gene description

 Homeobox B7

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nuclear bodies (supported)

Additional location

 In addition localized to the Cytosol (uncertain)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA049940
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies & nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported), Nuclear bodies (supported)

Additional location

 Cytosol (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049940 HEK 293 Nuclear bodies
HPA049940 MCF7 Nucleoplasm
Nuclear bodies
Cytosol
HPA049940 U-2 OS Nucleoplasm
Nuclear bodies
Cytosol

GENE INFORMATION

Gene name

 HOXB7 (HGNC Symbol)

Synonyms

 HOX2, HOX2C

Description

 Homeobox B7 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.32

Chromosome location (bp)

 48607227 - 48633572

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000260027 (version 83.38)

Entrez gene

 3217

UniProt

 P09629 (UniProt - Evidence at protein level)

neXtProt

 NX_P09629

Antibodypedia

 HOXB7 antibodies

PROTEIN BROWSER
HOXB7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXB7-001
ENSP00000239165
ENST00000239165
P09629 [Direct mapping]
Homeobox protein Hox-B7
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0009952 [anterior/posterior pattern specification]
GO:0030099 [myeloid cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
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 217 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.