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Several renal carcinomas as well as cases of liver cancers showed moderate cytoplasmic and nuclear staining. Cacner cells in general displayed weak cytoplasmic staining or were negative.
This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011]
