Expression of GAN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Gigaxonin

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049473	CAB011825

GENE INFORMATION
Gene name	GAN (HGNC Symbol)
Synonyms	GAN1, KLHL16
Description	Gigaxonin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
Chromosome	16
Cytoband	q23.2
Chromosome location (bp)	81314952 - 81390884
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261609 (version 83.38)
Entrez gene	8139
UniProt	Q9H2C0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2C0
Antibodypedia	GAN antibodies

PROTEIN BROWSER

GAN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAN-001 ENSP00000476795 ENST00000568107	Q9H2C0 [Direct mapping] Gigaxonin Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0016567 [protein ubiquitination] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	597 aa 67.6 kDa	No	0