Tissue expression of MMP12 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MMP12
Gene description	Matrix metallopeptidase 12
Protein class	Cancer-related genes Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix, urinary bladder)
FANTOM5:	Tissue enhanced (spleen, appendix)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, urinary bladder)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen, appendix)

GENE INFORMATION
Gene name	MMP12 (HGNC Symbol)
Synonyms	HME
Description	Matrix metallopeptidase 12 (HGNC Symbol)
Entrez gene summary	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q22.2
Chromosome location (bp)	102862736 - 102875034
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000262406 (version 83.38)
Entrez gene	4321
UniProt	P39900 (UniProt - Evidence at protein level)
neXtProt	NX_P39900
Antibodypedia	MMP12 antibodies

PROTEIN BROWSER

MMP12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MMP12-001 ENSP00000458585 ENST00000571244	P39900 [Direct mapping] Macrophage metalloelastase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0014070 [response to organic cyclic compound] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035313 [wound healing, spreading of epidermal cells] GO:0042493 [response to drug] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing] Show all	470 aa 54 kDa	Yes	0