Expression of MRPL12 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein L12

Protein class

Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA022853	HPA023043

GENE INFORMATION
Gene name	MRPL12 (HGNC Symbol)
Synonyms	MRPL7, MRPL7/L12, RPML12
Description	Mitochondrial ribosomal protein L12 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81703357 - 81707526
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000262814 (version 83.38)
Entrez gene	6182
UniProt	P52815 (UniProt - Evidence at protein level)
neXtProt	NX_P52815
Antibodypedia	MRPL12 antibodies

PROTEIN BROWSER

MRPL12-001	MRPL12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL12-001 ENSP00000333837 ENST00000333676	P52815 [Direct mapping] 39S ribosomal protein L12, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006390 [transcription from mitochondrial promoter] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	198 aa 21.3 kDa	No	0
MRPL12-201 ENSP00000439565 ENST00000541223	F6QW41 [Direct mapping] 39S ribosomal protein L12, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	178 aa 19.5 kDa	No	0