Cell atlas - FAM58A - The Human Protein Atlas

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FAM58A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM58A
Gene description	Family with sequence similarity 58, member A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059843
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059843	A-431	Nucleoplasm	Intensity
	HPA059843	MCF7	Nucleoplasm
	HPA059843	U-2 OS	Cytosol

GENE INFORMATION
Gene name	FAM58A (HGNC Symbol)
Synonyms	FLJ21610, MGC29729
Description	Family with sequence similarity 58, member A (HGNC Symbol)
Entrez gene summary	Mutations in this gene have been shown to cause an X-linked dominant STAR syndrome that typically manifests syndactyly, telecanthus and anogenital and renal malformations. The protein encoded by this gene contains a cyclin-box-fold domain which suggests it may have a role in controlling nuclear cell division cycles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153587919 - 153600045
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000262919 (version 83.38)
Entrez gene	92002
UniProt	Q8N1B3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N1B3
Antibodypedia	FAM58A antibodies

PROTEIN BROWSER

FAM58A-003	FAM58A-005	FAM58A-006	FAM58A-007	FAM58A-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM58A-003 ENSP00000484506 ENST00000614850	A0A087X1W3 [Direct mapping] Cyclin-related protein FAM58A Show all	Predicted intracellular proteins Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0019901 [protein kinase binding] Show all	170 aa 18.7 kDa	No	0
FAM58A-005 ENSP00000412865 ENST00000429336	H7C3N1 [Direct mapping] Cyclin-related protein FAM58A Show all	Predicted intracellular proteins Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0019901 [protein kinase binding] Show all	94 aa 11 kDa	No	0
FAM58A-006 ENSP00000461135 ENST00000576892	Q8N1B3 [Direct mapping] Cyclin-related protein FAM58A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain] Show all	248 aa 28.4 kDa	No	0
FAM58A-007 ENSP00000402949 ENST00000440428	Q8N1B3 [Direct mapping] Cyclin-related protein FAM58A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0032147 [activation of protein kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain] Show all	228 aa 26.1 kDa	No	0
FAM58A-011 ENSP00000466345 ENST00000482182	K7EM37 [Direct mapping] Cyclin-related protein FAM58A Show all	Predicted intracellular proteins Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0019901 [protein kinase binding] Show all	142 aa 16.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.