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Subsets of cells in a few squamous cell carcinomas along with single cases of melanoma and urothelial carcinoma showed strong cytoplasmic immunoreactivity. Remaining cancers were negative.
The majority of malignant cells displayed moderate cytoplasmic positivity. Additional membranous staining was observed in colorectal, endometrial, thyroid and breast cancers. Skin cancers along with most stomach and lung cancers were weakly stained or negative.