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Malignant tissues showed weak to moderate nuclear and cytoplasmic staining. A few cases of strong staining was seen in malignant gliomas and urothelial cancers.
GENE INFORMATION
Gene name
GJA5 (HGNC Symbol)
Synonyms
CX40
Description
Gap junction protein, alpha 5, 40kDa (HGNC Symbol)
Entrez gene summary
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]