Cell atlas - ANXA8 - The Human Protein Atlas

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ANXA8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ANXA8
Gene description	Annexin A8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HaCaT, hTCEpi, RT4, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA045246 , HPA047451
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, hTCEpi, RT4, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045246	A-431	Nucleoplasm
	HPA045246	RT4	Nucleoplasm
	HPA045246	U-2 OS	Nucleoplasm
	HPA047451	RT4	Nucleoplasm
	HPA047451	U-2 OS	No staining

GENE INFORMATION
Gene name	ANXA8 (HGNC Symbol)
Synonyms	ANX8
Description	Annexin A8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	47460162 - 47484158
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000265190 (version 83.38)
Entrez gene	653145
UniProt	P13928 (UniProt - Evidence at protein level)
neXtProt	NX_P13928
Antibodypedia	ANXA8 antibodies

PROTEIN BROWSER

ANXA8-001	ANXA8-002	ANXA8-004	ANXA8-201	ANXA8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANXA8-001 ENSP00000462880 ENST00000585281	P13928 [Direct mapping] Annexin A8 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007032 [endosome organization] GO:0007596 [blood coagulation] GO:0016197 [endosomal transport] GO:0031902 [late endosome membrane] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0051015 [actin filament binding] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900138 [negative regulation of phospholipase A2 activity] Show all	327 aa 36.9 kDa	No	0
ANXA8-002 ENSP00000464486 ENST00000583874	A0A075B765 [Direct mapping] Annexin Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	276 aa 30.7 kDa	No	0
ANXA8-004 ENSP00000462181 ENST00000583448	A0A075B748 [Direct mapping] Annexin A8 Show all	Predicted intracellular proteins Show all		21 aa 2.4 kDa	No	0
ANXA8-201 ENSP00000463091 ENST00000583911	P13928 [Direct mapping] Annexin A8 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007032 [endosome organization] GO:0007596 [blood coagulation] GO:0016197 [endosomal transport] GO:0031902 [late endosome membrane] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0051015 [actin filament binding] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900138 [negative regulation of phospholipase A2 activity] Show all	265 aa 30 kDa	No	0
ANXA8-202 ENSP00000478026 ENST00000611843	A0A087WTN9 [Direct mapping] Annexin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	365 aa 40.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.