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TXNIP

CANCER ATLAS

Gene description

 Thioredoxin interacting protein

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA031085
HPA053694

GENE INFORMATION

Gene name

 TXNIP (HGNC Symbol)

Synonyms

 EST01027, HHCPA78, THIF, VDUP1

Description

 Thioredoxin interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

 1

Cytoband

 q21.1

Chromosome location (bp)

 145992435 - 145996600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000265972 (version 83.38)

Entrez gene

 10628

UniProt

 Q9H3M7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3M7

Antibodypedia

 TXNIP antibodies

PROTEIN BROWSER
TXNIP-001
TXNIP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNIP-001
ENSP00000462521
ENST00000582401
Q9H3M7 [Direct mapping]
Thioredoxin-interacting protein
A0A024R4B7 [Target identity:100%; Query identity:100%]
Thioredoxin interacting protein, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005758 [mitochondrial intermembrane space]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006606 [protein import into nucleus]
GO:0006979 [response to oxidative stress]
GO:0007049 [cell cycle]
GO:0009612 [response to mechanical stimulus]
GO:0009749 [response to glucose]
GO:0030216 [keratinocyte differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032355 [response to estradiol]
GO:0032570 [response to progesterone]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043065 [positive regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051592 [response to calcium ion]
GO:0051782 [negative regulation of cell division]
GO:0071228 [cellular response to tumor cell]
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 391 aa
43.7 kDa 		No 0
TXNIP-002
ENSP00000396322
ENST00000425134
Q9H3M7 [Direct mapping]
Thioredoxin-interacting protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0030216 [keratinocyte differentiation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0051782 [negative regulation of cell division]
GO:0071228 [cellular response to tumor cell]
Show all
 336 aa
37.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.