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Most cancer tissues exhibited weak to moderate cytoplasmic immunoreactivity. Several squamous cell carcinomas and papillary adenocarcinomas of thyroid were strongly stained. Testicular, ovarian and renal cancers cases were mainly negative.
This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]