Expression of SSX4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Synovial sarcoma, X breakpoint 4

Protein class

Cancer-related genes, Predicted intracellular proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA045683

GENE INFORMATION
Gene name	SSX4 (HGNC Symbol)
Synonyms	CT5.4
Description	Synovial sarcoma, X breakpoint 4 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48383516 - 48393347
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000268009 (version 83.38)
Entrez gene	6759
UniProt	O60224 (UniProt - Evidence at transcript level)
neXtProt	NX_O60224
Antibodypedia	SSX4 antibodies

PROTEIN BROWSER

SSX4-001	SSX4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSX4-001 ENSP00000469011 ENST00000595689	O60224 [Direct mapping] Protein SSX4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	188 aa 21.9 kDa	No	0
SSX4-201 ENSP00000483262 ENST00000620320	O60224 [Direct mapping] Protein SSX4 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	153 aa 17.9 kDa	No	0