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GABRQ

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GENERAL INFORMATION

Gene name

 GABRQ

Gene description

 Gamma-aminobutyric acid (GABA) A receptor, theta

Protein class

 FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (U-87 MG, SiHa, HeLa)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-87 MG, SiHa, HeLa)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GABRQ (HGNC Symbol)

Synonyms

 THETA

Description

 Gamma-aminobutyric acid (GABA) A receptor, theta (HGNC Symbol)

Entrez gene summary

 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 152638183 - 152657534

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000268089 (version 83.38)

Entrez gene

 55879

UniProt

 Q9UN88 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UN88

Antibodypedia

 GABRQ antibodies

PROTEIN BROWSER
GABRQ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABRQ-001
ENSP00000469332
ENST00000598523
Q9UN88 [Direct mapping]
Gamma-aminobutyric acid receptor subunit theta
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005326 [neurotransmitter transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 632 aa
72 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.