Expression of SPIB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Spi-B transcription factor (Spi-1/PU.1 related)

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018523

GENE INFORMATION
Gene name	SPIB (HGNC Symbol)
Synonyms	SPI-B
Description	Spi-B transcription factor (Spi-1/PU.1 related) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	50418938 - 50431313
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000269404 (version 83.38)
Entrez gene	6689
UniProt	Q01892 (UniProt - Evidence at protein level)
neXtProt	NX_Q01892
Antibodypedia	SPIB antibodies

PROTEIN BROWSER

SPIB-001	SPIB-002	SPIB-003	SPIB-006	SPIB-007	SPIB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPIB-001 ENSP00000471921 ENST00000595883	Q01892 [Direct mapping] Transcription factor Spi-B A0A024R4I5 [Target identity:100%; Query identity:100%] Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_b Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] Show all	262 aa 28.8 kDa	No	0
SPIB-002 ENSP00000470970 ENST00000596074	M0R037 [Direct mapping] Transcription factor Spi-B Show all	Predicted intracellular proteins Show all		77 aa 7.9 kDa	No	0
SPIB-003 ENSP00000270632 ENST00000270632	Q01892 [Direct mapping] Transcription factor Spi-B Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] Show all	177 aa 18.6 kDa	No	0
SPIB-006 ENSP00000472626 ENST00000594685	M0R2J9 [Direct mapping] Transcription factor Spi-B Show all	Predicted intracellular proteins Show all		127 aa 13.4 kDa	No	0
SPIB-007 ENSP00000469023 ENST00000597855	M0QXA8 [Direct mapping] Transcription factor Spi-B Show all	Predicted intracellular proteins Show all		137 aa 14.3 kDa	No	0
SPIB-201 ENSP00000391877 ENST00000439922	Q01892 [Direct mapping] Transcription factor Spi-B Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] Show all	171 aa 19.1 kDa	No	0