Cell atlas - TMEM185A - The Human Protein Atlas

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TMEM185A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	TMEM185A
Gene description	Transmembrane protein 185A
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071744
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071744	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	TMEM185A (HGNC Symbol)
Synonyms	CXorf13, FAM11A, FRAXF
Description	Transmembrane protein 185A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	149596556 - 149631912
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000269556 (version 83.38)
Entrez gene	84548
UniProt	Q8NFB2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFB2
Antibodypedia	TMEM185A antibodies

PROTEIN BROWSER

TMEM185A-001	TMEM185A-002	TMEM185A-005	TMEM185A-006	TMEM185A-201	TMEM185A-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM185A-001 ENSP00000471932 ENST00000600449	Q8NFB2 [Direct mapping] Transmembrane protein 185A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] Show all	350 aa 40.6 kDa	No	8
TMEM185A-002 ENSP00000427766 ENST00000507237	E7EMM1 [Direct mapping] Transmembrane protein 185A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	173 aa 20.1 kDa	No	5
TMEM185A-005 ENSP00000428659 ENST00000511776	E5RGV1 [Direct mapping] Transmembrane protein 185A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	60 aa 7 kDa	No	1
TMEM185A-006 ENSP00000427814 ENST00000502858	H0YAP3 [Direct mapping] Transmembrane protein 185A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	223 aa 25.9 kDa	No	3
TMEM185A-201 ENSP00000483235 ENST00000611119	B7Z4G6 [Direct mapping] Transmembrane protein 185A; cDNA FLJ52946, highly similar to Protein FAM11A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	291 aa 33.9 kDa	No	6
TMEM185A-202 ENSP00000482375 ENST00000613273	B3KY49 [Direct mapping] Family with sequence similarity 11, member A, isoform CRA_a; Transmembrane protein 185A; cDNA FLJ46855 fis, clone UTERU3010029, highly similar to Protein FAM11A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	172 aa 20 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.