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Several renal cancers exhibited moderate cytoplasmic, nuclear and membranous positivity. A few cases of hepatocellular and urothelial carcinomas showed moderate cytoplasmic and nuclear staining. Remaining cancer tissues were negative.
Several cases of squamous cell carcinomas of lung, cervix, skin, papillary adenocarcinomas of thyroid, ovarian, colorectal and pancreatic cancers showed moderate to strong membranous staining. Remaining cancer tissues were weakly stained or negative.
Subsets of cells in a few squamous cell carcinomas along with single cases of melanoma and urothelial carcinoma showed strong cytoplasmic immunoreactivity. Remaining cancers were negative.
A single case of squamous cell carcinoma of head and neck cancer showed moderate nuclear immunoreactivity. Rare cases of endometrial, thyroid and pancreatic cancers exhibited weak nuclear staining. Remaining cancer tissues were negative.
Most liver cancers, lobular carcinomas of breast and adenocarcinomas of lung along with few stomach cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
NBPF19
Synonyms
Description
Neuroblastoma breakpoint family, member 19 (HGNC Symbol)
