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Most cancer cells displayed weak to moderate cytoplasmic staining. Several colorectal cancers along with a few ovarian, stomach, liver and pancreatic cancers showed strong immunoreactivity. Several lymphomas, testis, renal and cervical cancers were negative.
Rare case of glioma and breast cancer displayed strong cytoplasmic staining. Moderate positivity was observed in occasional cases of ovarian, cervical, endometrial and pancreatic cancers. Remaining cancer tissues were weakly stained or negative.
Several renal cancers exhibited moderate cytoplasmic, nuclear and membranous positivity. A few cases of hepatocellular and urothelial carcinomas showed moderate cytoplasmic and nuclear staining. Remaining cancer tissues were negative.
Several cases of squamous cell carcinomas of lung, cervix, skin, papillary adenocarcinomas of thyroid, ovarian, colorectal and pancreatic cancers showed moderate to strong membranous staining. Remaining cancer tissues were weakly stained or negative.
A single case of squamous cell carcinoma of head and neck cancer showed moderate nuclear immunoreactivity. Rare cases of endometrial, thyroid and pancreatic cancers exhibited weak nuclear staining. Remaining cancer tissues were negative.
Most liver cancers, lobular carcinomas of breast and adenocarcinomas of lung along with few stomach cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
NBPF10 (HGNC Symbol)
Synonyms
AG1
Description
Neuroblastoma breakpoint family, member 10 (HGNC Symbol)
Entrez gene summary
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
