Tissue expression of KMT2B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KMT2B
Gene description	Lysine (K)-specific methyltransferase 2B
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	KMT2B (HGNC Symbol)
Synonyms	CXXC10, HRX2, KIAA0304, MLL1B, MLL2, MLL4, TRX2, WBP7
Description	Lysine (K)-specific methyltransferase 2B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35718019 - 35738878
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000272333 (version 83.38)
Entrez gene	9757
UniProt	Q9UMN6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UMN6
Antibodypedia	KMT2B antibodies

PROTEIN BROWSER

KMT2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KMT2B-001 ENSP00000398837 ENST00000420124	Q9UMN6 [Direct mapping] Histone-lysine N-methyltransferase 2B Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Show all	GO:0001541 [ovarian follicle development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007613 [memory] GO:0008270 [zinc ion binding] GO:0009994 [oocyte differentiation] GO:0016458 [gene silencing] GO:0030728 [ovulation] GO:0034968 [histone lysine methylation] GO:0035097 [histone methyltransferase complex] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0051568 [histone H3-K4 methylation] GO:0051569 [regulation of histone H3-K4 methylation] GO:0080182 [histone H3-K4 trimethylation] Show all	2715 aa 293.5 kDa	No	0