Cell atlas - DCP1A - The Human Protein Atlas

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DCP1A

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytoplasmic bodies

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	DCP1A
Gene description	Decapping mRNA 1A
Protein class	Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytoplasmic bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytoplasmic bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA013202
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytoplasmic bodies.

Main location

Cytoplasmic bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA013202	A-431	Cytoplasmic bodies
	HPA013202	U-2 OS	Cytoplasmic bodies
	HPA013202	U-251 MG	Cytoplasmic bodies

GENE INFORMATION
Gene name	DCP1A (HGNC Symbol)
Synonyms	HSA275986, SMAD4IP1, SMIF
Description	Decapping mRNA 1A (HGNC Symbol)
Entrez gene summary	Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	53283428 - 53347610
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000272886 (version 83.38)
Entrez gene	55802
UniProt	Q9NPI6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPI6
Antibodypedia	DCP1A antibodies

PROTEIN BROWSER

DCP1A-001	DCP1A-004	DCP1A-009	DCP1A-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCP1A-001 ENSP00000476386 ENST00000610213	Q9NPI6 [Direct mapping] mRNA-decapping enzyme 1A Show all	Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932 [cytoplasmic mRNA processing body] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0042802 [identical protein binding] GO:0043488 [regulation of mRNA stability] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] Show all	582 aa 63.3 kDa	No	0
DCP1A-004 ENSP00000476046 ENST00000294241	Q9NPI6 [Direct mapping] mRNA-decapping enzyme 1A Show all	Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932 [cytoplasmic mRNA processing body] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0042802 [identical protein binding] GO:0043488 [regulation of mRNA stability] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] Show all	544 aa 59.3 kDa	No	0
DCP1A-009 ENSP00000477594 ENST00000560624	A0A087WT55 [Direct mapping] mRNA-decapping enzyme 1A Show all	Predicted intracellular proteins Show all		260 aa 29.1 kDa	No	0
DCP1A-010 ENSP00000479387 ENST00000559748	A0A087WVE6 [Direct mapping] mRNA-decapping enzyme 1A Show all	Predicted intracellular proteins Show all		191 aa 21.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.