Tissue expression of CYFIP1 - Summary - The Human Protein Atlas

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CYFIP1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CYFIP1
Gene description	Cytoplasmic FMR1 interacting protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, including CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA068106
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CYFIP1 (HGNC Symbol)
Synonyms	KIAA0068, P140SRA-1, SHYC
Description	Cytoplasmic FMR1 interacting protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q11.2
Chromosome location (bp)	22867052 - 22981063
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000273749 (version 83.38)
Entrez gene	23191
UniProt	Q7L576 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L576
Antibodypedia	CYFIP1 antibodies

PROTEIN BROWSER

CYFIP1-001	CYFIP1-003	CYFIP1-004	CYFIP1-015	CYFIP1-016	CYFIP1-017	CYFIP1-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYFIP1-001 ENSP00000481038 ENST00000617928	Q7L576 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0005925 [focal adhesion] GO:0007264 [small GTPase mediated signal transduction] GO:0008360 [regulation of cell shape] GO:0016601 [Rac protein signal transduction] GO:0030027 [lamellipodium] GO:0030032 [lamellipodium assembly] GO:0031209 [SCAR complex] GO:0031529 [ruffle organization] GO:0032403 [protein complex binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043005 [neuron projection] GO:0045087 [innate immune response] GO:0045202 [synapse] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048365 [Rac GTPase binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050890 [cognition] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation] Show all	1253 aa 145.2 kDa	No	0
CYFIP1-003 ENSP00000478779 ENST00000610365	Q7L576 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0005925 [focal adhesion] GO:0007264 [small GTPase mediated signal transduction] GO:0008360 [regulation of cell shape] GO:0016601 [Rac protein signal transduction] GO:0030027 [lamellipodium] GO:0030032 [lamellipodium assembly] GO:0031209 [SCAR complex] GO:0031529 [ruffle organization] GO:0032403 [protein complex binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043005 [neuron projection] GO:0045087 [innate immune response] GO:0045202 [synapse] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048365 [Rac GTPase binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050890 [cognition] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation] Show all	1253 aa 145.2 kDa	No	0
CYFIP1-004 ENSP00000480525 ENST00000617556	Q7L576 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0005925 [focal adhesion] GO:0007264 [small GTPase mediated signal transduction] GO:0008360 [regulation of cell shape] GO:0016601 [Rac protein signal transduction] GO:0030027 [lamellipodium] GO:0030032 [lamellipodium assembly] GO:0031209 [SCAR complex] GO:0031529 [ruffle organization] GO:0032403 [protein complex binding] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043005 [neuron projection] GO:0045087 [innate immune response] GO:0045202 [synapse] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048365 [Rac GTPase binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050890 [cognition] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation] Show all	822 aa 94.5 kDa	No	0
CYFIP1-015 ENSP00000453060 ENST00000561263	H0YL50 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		176 aa 20.2 kDa	No	0
CYFIP1-016 ENSP00000480307 ENST00000613006	A0A087WWL1 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	Predicted intracellular proteins Show all		161 aa 18.7 kDa	No	0
CYFIP1-017 ENSP00000478377 ENST00000611832	A0A087WU52 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	Predicted intracellular proteins Show all		151 aa 17.6 kDa	No	0
CYFIP1-020 ENSP00000479802 ENST00000612288	A0A087WVZ5 [Direct mapping] Cytoplasmic FMR1-interacting protein 1 Show all	Predicted intracellular proteins Show all		185 aa 21 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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