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GGTLC3

GENERAL INFORMATION

Gene name

 GGTLC3

Gene description

 Gamma-glutamyltransferase light chain 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lung, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 2 antibodies.
HPA045635 , HPA047534
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, testis)

GENE INFORMATION

Gene name

 GGTLC3

Synonyms

Description

 Gamma-glutamyltransferase light chain 3 (HGNC Symbol)

Entrez gene summary

 GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 18516344 - 18518161

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000274252 (version 83.38)

Entrez gene

 728441

UniProt

 B5MD39 (UniProt - Uncertain)

neXtProt

 NX_B5MD39

Antibodypedia

 GGTLC3 antibodies

PROTEIN BROWSER
GGTLC3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GGTLC3-001
ENSP00000477856
ENST00000619998
B5MD39 [Direct mapping]
Putative gamma-glutamyltransferase light chain 3
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0003840 [gamma-glutamyltransferase activity]
GO:0006749 [glutathione metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0070062 [extracellular exosome]
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 225 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.