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CCL23

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GENERAL INFORMATION

Gene name

 CCL23

Gene description

 Chemokine (C-C motif) ligand 23

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (THP-1, HEL, U-937)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (THP-1, HEL, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CCL23 (HGNC Symbol)

Synonyms

 Ckb-8, CKb8, MIP-3, MPIF-1, SCYA23

Description

 Chemokine (C-C motif) ligand 23 (HGNC Symbol)

Entrez gene summary

 This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 36013056 - 36017968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000274736 (version 83.38)

Entrez gene

 6368

UniProt

 P55773 (UniProt - Evidence at protein level)

neXtProt

 NX_P55773

Antibodypedia

 CCL23 antibodies

PROTEIN BROWSER
CCL23-001
CCL23-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL23-001
ENSP00000481357
ENST00000615050
P55773 [Direct mapping]
C-C motif chemokine 23 CCL23(19-99) CCL23(22-99) CCL23(27-99) CCL23(30-99)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0030593 [neutrophil chemotaxis]
GO:0031726 [CCR1 chemokine receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:2001264 [negative regulation of C-C chemokine binding]
Show all
 137 aa
15.3 kDa 		Yes 0
CCL23-002
ENSP00000484748
ENST00000612516
P55773 [Direct mapping]
C-C motif chemokine 23 CCL23(19-99) CCL23(22-99) CCL23(27-99) CCL23(30-99)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0030593 [neutrophil chemotaxis]
GO:0031726 [CCR1 chemokine receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:2001264 [negative regulation of C-C chemokine binding]
Show all
 120 aa
13.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.