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Few pancreas, stomach, breast and ovary cancers showed moderate membranous positivity. Other cancer tissues were in general weakly stained or negative.
Few cases of pancreatic adenocarcinomas showed strong cytoplasmic staining. Remaining cancers were negative.
GENE INFORMATION
Gene name
PRSS2 (HGNC Symbol)
Synonyms
TRY2
Description
Protease, serine, 2 (trypsin 2) (HGNC Symbol)
Entrez gene summary
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
