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HIST1H2AL

GENERAL INFORMATION

Gene name

 HIST1H2AL

Gene description

 Histone cluster 1, H2al

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

 Supported based on 1 antibody.
HPA041189
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 HIST1H2AL (HGNC Symbol)

Synonyms

 dJ193B12.9, H2A/i, H2AFI

Description

 Histone cluster 1, H2al (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 27865355 - 27865747

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000276903 (version 83.38)

Entrez gene

 8332

UniProt

 P0C0S8 (UniProt - Evidence at protein level)

neXtProt

 NX_P0C0S8

Antibodypedia

 HIST1H2AL antibodies

PROTEIN BROWSER
HIST1H2AL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H2AL-001
ENSP00000482538
ENST00000613174
P0C0S8 [Direct mapping]
Histone H2A type 1
A4FTV9 [Target identity:100%; Query identity:100%]
Histone H2A
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0019899 [enzyme binding]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 130 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.