Tissue expression of PCGF2 - Summary - The Human Protein Atlas

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PCGF2

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PCGF2
Gene description	Polycomb group ring finger 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047732
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PCGF2 (HGNC Symbol)
Synonyms	MEL-18, RNF110, ZNF144
Description	Polycomb group ring finger 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	38733897 - 38749817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000277258 (version 83.38)
Entrez gene	7703
UniProt	P35227 (UniProt - Evidence at protein level)
neXtProt	NX_P35227
Antibodypedia	PCGF2 antibodies

PROTEIN BROWSER

PCGF2-001	PCGF2-002	PCGF2-003	PCGF2-004	PCGF2-005	PCGF2-006	PCGF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCGF2-001 ENSP00000484201 ENST00000616129	J3KT13 [Direct mapping] Polycomb group RING finger protein 2; Polycomb group ring finger 2, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	257 aa 28.5 kDa	No	0
PCGF2-002 ENSP00000482063 ENST00000616199	P35227 [Direct mapping] Polycomb group RING finger protein 2 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001701 [in utero embryonic development] GO:0001739 [sex chromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0009952 [anterior/posterior pattern specification] GO:0016573 [histone acetylation] GO:0016604 [nuclear body] GO:0016925 [protein sumoylation] GO:0031519 [PcG protein complex] GO:0035102 [PRC1 complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0070301 [cellular response to hydrogen peroxide] GO:2001234 [negative regulation of apoptotic signaling pathway] Show all	344 aa 37.8 kDa	No	0
PCGF2-003 ENSP00000484721 ENST00000618506	A0A087X259 [Direct mapping] Polycomb group RING finger protein 2 Show all	Predicted intracellular proteins Show all		203 aa 22.3 kDa	No	0
PCGF2-004 ENSP00000481656 ENST00000618941	J3KT13 [Direct mapping] Polycomb group RING finger protein 2; Polycomb group ring finger 2, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	257 aa 28.5 kDa	No	0
PCGF2-005 ENSP00000478970 ENST00000611883	P35227 [Direct mapping] Polycomb group RING finger protein 2 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016925 [protein sumoylation] GO:0031519 [PcG protein complex] GO:0035102 [PRC1 complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] Show all	344 aa 37.8 kDa	No	0
PCGF2-006 ENSP00000483741 ENST00000610747	A0A087X0Y6 [Direct mapping] Polycomb group RING finger protein 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		66 aa 6.9 kDa	No	0
PCGF2-201 ENSP00000482815 ENST00000620225	P35227 [Direct mapping] Polycomb group RING finger protein 2 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016925 [protein sumoylation] GO:0031519 [PcG protein complex] GO:0035102 [PRC1 complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] Show all	344 aa 37.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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