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Moderate cytoplasmic and/or nuclear immunoreactivity was observed in most tumour tissues. Occasional melanomas, lung and endometrial cancers were strongly stained. Testicular, gastric, renal, urothelial and pancreatic cancers were weakly stained or generally negative.
Most tumour tissues showed moderate to strong cytoplasmic positivity. Few squamous cell carcinomas of uterine cervix and lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
PSMB3 (HGNC Symbol)
Synonyms
HC10-II, MGC4147
Description
Proteasome subunit beta 3 (HGNC Symbol)
Entrez gene summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]