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SSTR3

CANCER ATLAS

Gene description

 Somatostatin receptor 3

Protein class

 G-protein coupled receptors, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB022647

GENE INFORMATION

Gene name

 SSTR3

Synonyms

Description

 Somatostatin receptor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 37204238 - 37212322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000278195 (version 83.38)

Entrez gene

 6753

UniProt

 P32745 (UniProt - Evidence at protein level)

neXtProt

 NX_P32745

Antibodypedia

 SSTR3 antibodies

PROTEIN BROWSER
SSTR3-001
SSTR3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSTR3-001
ENSP00000480971
ENST00000610913
P32745 [Direct mapping]
Somatostatin receptor type 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004994 [somatostatin receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007267 [cell-cell signaling]
GO:0007283 [spermatogenesis]
GO:0008285 [negative regulation of cell proliferation]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030900 [forebrain development]
GO:0031513 [nonmotile primary cilium]
GO:0038170 [somatostatin signaling pathway]
GO:0042594 [response to starvation]
GO:0060170 [ciliary membrane]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 418 aa
45.8 kDa 		No 7
SSTR3-002
ENSP00000481325
ENST00000617123
P32745 [Direct mapping]
Somatostatin receptor type 3
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004994 [somatostatin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006996 [organelle organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007267 [cell-cell signaling]
GO:0008285 [negative regulation of cell proliferation]
GO:0008628 [hormone-mediated apoptotic signaling pathway]
GO:0016021 [integral component of membrane]
GO:0031513 [nonmotile primary cilium]
GO:0038170 [somatostatin signaling pathway]
GO:0060170 [ciliary membrane]
Show all
 418 aa
45.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.