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NR2E3

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GENERAL INFORMATION

Gene name

 NR2E3

Gene description

 Nuclear receptor subfamily 2, group E, member 3

Protein class

 Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NR2E3 (HGNC Symbol)

Synonyms

 PNR, rd7, RP37

Description

 Nuclear receptor subfamily 2, group E, member 3 (HGNC Symbol)

Entrez gene summary

 This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 71792638 - 71818259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000278570 (version 83.38)

Entrez gene

 10002

UniProt

 Q9Y5X4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5X4

Antibodypedia

 NR2E3 antibodies

PROTEIN BROWSER
NR2E3-001
NR2E3-002
NR2E3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR2E3-001
ENSP00000482504
ENST00000617575
Q9Y5X4 [Direct mapping]
Photoreceptor-specific nuclear receptor
Show all
Nuclear receptors
   Phobius predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042462 [eye photoreceptor cell development]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045872 [positive regulation of rhodopsin gene expression]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060041 [retina development in camera-type eye]
Show all
 410 aa
44.7 kDa 		No 0
NR2E3-002
ENSP00000479962
ENST00000621098
Q9Y5X4 [Direct mapping]
Photoreceptor-specific nuclear receptor
F1D8Q9 [Target identity:100%; Query identity:100%]
Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b; Photoreceptor cell-specific nuclear receptor variant 1
Show all
Nuclear receptors
   Phobius predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 367 aa
39.6 kDa 		No 0
NR2E3-004
ENSP00000479254
ENST00000621736
Q8IVZ9 [Direct mapping]
NR2E3 protein; Photoreceptor-specific nuclear receptor
Show all
Nuclear receptors
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 322 aa
35.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.