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Most cancer tissues displayed weak to moderate nuclear immunoreactivity with additional cytoplasmic positivity in several cases. Malignant lymphomas along with a few squamous cell carcinomas and colorectal cancers were strongly stained. Testicular cancers were negative.
GENE INFORMATION
Gene name
AC009950.1
Synonyms
Description
Entrez gene summary
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
