THE HUMAN PROTEIN ATLAS BLOG

TACO1 an ubiquitous protein governing expression of the mitochondrial genome

2017-04-21
Cell Atlas cells Image of the week Immunofluorescence microscopy Mitochondria Mitochondrial disorders

Antibody HPA021643 in U-2 OS recognizing TACO1 in mitochondria.

Mitochondria harbors an own genome that renders key proteins involved in production of energy through oxidation of various substrates. Majority of the disorders associated with mitochondrial function are caused by impaired expression of the proteins encoded in the mitochondrial genome. One of these proteins is the translational activator of cytochrome c oxidase 1 (TACO1).

Experimental results reveal that TACO1 is expressed in all tissues within the human body. The protein is detected mainly in the cytoplasm and more precise inside mitochondria. Explore expression and subcellular localization of TACO1 in the Cell Atlas...Read more


Mad about Mitochondria

2016-09-20
Cell Atlas Mitochondria Subcell Atlas

Mikaela Wiking

This week, it is Mitochondrial Disease Awareness Week. Therefore we would like to take the opportunity to talk about the mitochondrial proteome, the work we do within this field, and you will even get to meet one of our researchers, involved in this work.

The mitochondria are distributed throughout the cytoplasm of the cell, each organelle enclosed by a double membrane, the inner one forming the characteristic folds known as cristae. Mitochondria are essential for producing the cell´s need of ATP through cellular respiration, but have also been shown to participate in many other cellular functions, including apoptosis, calcium storage and cellular signaling...Read more


Image of the week - Mitochondria by Illuminator

2016-06-17
Image of the week Mitochondria Subcell Atlas

Figure 1. Staining of TOMM5 (green) with DNA (blue) in HeLa cells.

Welcome back to Image of The Week! We will be periodically highlighting an organelle in the coming image of the week posts, written by members of the Subcellular Human Protein Atlas project. This week we kick things off with a post by HPA_Illuminator, and what better way to start than with the mitochondria, the (true) powerhouse of the cell!!!

Mitochondria are found in almost all human cells, in varying numbers. They are known as the powerhouse of the cell as they are responsible for producing the majority of the energy in your body (in the form of ATP, adenosine triphosphate)...Read more


Image of the week - FDXR by solartech0

2016-06-10
Citizen Science Image of the week Mitochondria Project Discovery Subcell Atlas

Figure 1. Staining of FDXR (green) with DNA (blue) and microtubules (red) in A549 cells.

Welcome to HPA image of the week! This week's image was brought to us by citizen scientists in Project Discovery, and specifically by solartech0 who found this image while playing Project Discovery in EVE online.

The protein stained in Fig 1. is an image of ferredoxin reductase (FDXR) found in the mitochondria of the cell. This sample shows a staining of FDXR in A549 adenocarcinomic alveolar basal epithelial cells.

FDXR is a protein involved in cellular metabolism. This process is what provides energy for our cells and is carried out in the mitochondria of the cell...Read more


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