Expression of HS3ST1 in cancer - Summary

CANCER ATLAS

Gene description

Heparan sulfate (glucosamine) 3-O-sulfotransferase 1

Protein class

Enzymes, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA002237

GENE INFORMATION
Gene name	HS3ST1 (HGNC Symbol)
Synonyms	3OST1
Description	Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 (HGNC Symbol)
Entrez gene summary	Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p15.33
Chromosome location (bp)	11393150 - 11429765
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002587 (version 83.38)
Entrez gene	9957
UniProt	O14792 (UniProt - Evidence at protein level)
neXtProt	NX_O14792
Antibodypedia	HS3ST1 antibodies

PROTEIN BROWSER

HS3ST1-001	HS3ST1-002	HS3ST1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS3ST1-001 ENSP00000002596 ENST00000002596	O14792 [Direct mapping] Heparan sulfate glucosamine 3-O-sulfotransferase 1 A0A024R9R4 [Target identity:100%; Query identity:100%] Sulfotransferase Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0008467 [[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] Show all	307 aa 35.8 kDa	Yes	0
HS3ST1-002 ENSP00000422629 ENST00000510712	E9PDE3 [Direct mapping] Heparan sulfate glucosamine 3-O-sulfotransferase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		83 aa 8.6 kDa	Yes	0
HS3ST1-003 ENSP00000425673 ENST00000514690	E9PDE3 [Direct mapping] Heparan sulfate glucosamine 3-O-sulfotransferase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		83 aa 8.6 kDa	Yes	0