Cell atlas - HS3ST1 - The Human Protein Atlas

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HS3ST1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	HS3ST1
Gene description	Heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (CAPAN-2, RPTEC TERT1, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002237
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, RPTEC TERT1, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002237	A-431	Vesicles
	HPA002237	RT4	Vesicles
	HPA002237	U-2 OS	No staining

GENE INFORMATION
Gene name	HS3ST1 (HGNC Symbol)
Synonyms	3OST1
Description	Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 (HGNC Symbol)
Entrez gene summary	Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p15.33
Chromosome location (bp)	11393150 - 11429765
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002587 (version 83.38)
Entrez gene	9957
UniProt	O14792 (UniProt - Evidence at protein level)
neXtProt	NX_O14792
Antibodypedia	HS3ST1 antibodies

PROTEIN BROWSER

HS3ST1-001	HS3ST1-002	HS3ST1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS3ST1-001 ENSP00000002596 ENST00000002596	O14792 [Direct mapping] Heparan sulfate glucosamine 3-O-sulfotransferase 1 A0A024R9R4 [Target identity:100%; Query identity:100%] Sulfotransferase Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0008146 [sulfotransferase activity] GO:0008467 [[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] Show all	307 aa 35.8 kDa	Yes	0
HS3ST1-002 ENSP00000422629 ENST00000510712	E9PDE3 [Direct mapping] Heparan sulfate glucosamine 3-O-sulfotransferase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		83 aa 8.6 kDa	Yes	0
HS3ST1-003 ENSP00000425673 ENST00000514690	E9PDE3 [Direct mapping] Heparan sulfate glucosamine 3-O-sulfotransferase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		83 aa 8.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.