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MAD1L1

CANCER ATLAS

Gene description

 MAD1 mitotic arrest deficient-like 1 (yeast)

Protein class

 Disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003635
CAB015338

GENE INFORMATION

Gene name

 MAD1L1 (HGNC Symbol)

Synonyms

 HsMAD1, MAD1, PIG9, TP53I9, TXBP181

Description

 MAD1 mitotic arrest deficient-like 1 (yeast) (HGNC Symbol)

Entrez gene summary

 MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 7

Cytoband

 p22.3

Chromosome location (bp)

 1815793 - 2233243

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000002822 (version 83.38)

Entrez gene

 8379

UniProt

 Q9Y6D9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6D9

Antibodypedia

 MAD1L1 antibodies

PROTEIN BROWSER
«
MAD1L1-001
MAD1L1-002
MAD1L1-003
MAD1L1-004
MAD1L1-005
MAD1L1-006
MAD1L1-007
MAD1L1-013
MAD1L1-014
MAD1L1-016
MAD1L1-017
MAD1L1-018
MAD1L1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAD1L1-001
ENSP00000382562
ENST00000399654
Q9Y6D9 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
GO:0090235 [regulation of metaphase plate congression]
Show all
 718 aa
83.1 kDa 		No 0
MAD1L1-002
ENSP00000384155
ENST00000402746
Q9Y6D9 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
GO:0090235 [regulation of metaphase plate congression]
Show all
 626 aa
72.3 kDa 		Yes 0
MAD1L1-003
ENSP00000385334
ENST00000406869
Q9Y6D9 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0042130 [negative regulation of T cell proliferation]
GO:0048538 [thymus development]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
GO:0090235 [regulation of metaphase plate congression]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
 718 aa
83.1 kDa 		No 0
MAD1L1-004
ENSP00000395457
ENST00000429779
C9JJ38 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 157 aa
18.2 kDa 		No 0
MAD1L1-005
ENSP00000390099
ENST00000455998
C9JIR0 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 144 aa
16.6 kDa 		No 0
MAD1L1-006
ENSP00000413139
ENST00000429625
C9K086 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 213 aa
25.3 kDa 		No 0
MAD1L1-007
ENSP00000401901
ENST00000445959
C9JTA2 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 205 aa
24.2 kDa 		No 0
MAD1L1-013
ENSP00000393037
ENST00000444373
C9JX80 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 80 aa
9 kDa 		No 0
MAD1L1-014
ENSP00000397417
ENST00000421113
C9J9H5 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 41 aa
4.7 kDa 		No 0
MAD1L1-016
ENSP00000414877
ENST00000438959
C9JPS1 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
Show all
 199 aa
23.1 kDa 		No 0
MAD1L1-017
ENSP00000394886
ENST00000450235
C9JP81 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0015629 [actin cytoskeleton]
Show all
 266 aa
30.6 kDa 		No 0
MAD1L1-018
ENSP00000394069
ENST00000437877
C9JKI7 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0015629 [actin cytoskeleton]
Show all
 122 aa
13.9 kDa 		No 0
MAD1L1-201
ENSP00000265854
ENST00000265854
Q9Y6D9 [Direct mapping]
Mitotic spindle assembly checkpoint protein MAD1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
GO:0090235 [regulation of metaphase plate congression]
Show all
 718 aa
83.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.