Tissue expression of MAD1L1 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MAD1L1

premium

TISSUE

premium

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MAD1L1
Gene description	MAD1 mitotic arrest deficient-like 1 (yeast)
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	13
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear and nuclear membrane expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA003635 , CAB015338
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MAD1L1 (HGNC Symbol)
Synonyms	HsMAD1, MAD1, PIG9, TP53I9, TXBP181
Description	MAD1 mitotic arrest deficient-like 1 (yeast) (HGNC Symbol)
Entrez gene summary	MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	1815793 - 2233243
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002822 (version 83.38)
Entrez gene	8379
UniProt	Q9Y6D9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6D9
Antibodypedia	MAD1L1 antibodies

PROTEIN BROWSER

MAD1L1-001	MAD1L1-002	MAD1L1-003	MAD1L1-004	MAD1L1-005	MAD1L1-006	MAD1L1-007	MAD1L1-013	MAD1L1-014	MAD1L1-016	MAD1L1-017	MAD1L1-018	MAD1L1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAD1L1-001 ENSP00000382562 ENST00000399654	Q9Y6D9 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007264 [small GTPase mediated signal transduction] GO:0015629 [actin cytoskeleton] GO:0051301 [cell division] GO:0072686 [mitotic spindle] GO:0090235 [regulation of metaphase plate congression] Show all	718 aa 83.1 kDa	No	0
MAD1L1-002 ENSP00000384155 ENST00000402746	Q9Y6D9 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007264 [small GTPase mediated signal transduction] GO:0015629 [actin cytoskeleton] GO:0051301 [cell division] GO:0072686 [mitotic spindle] GO:0090235 [regulation of metaphase plate congression] Show all	626 aa 72.3 kDa	Yes	0
MAD1L1-003 ENSP00000385334 ENST00000406869	Q9Y6D9 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007264 [small GTPase mediated signal transduction] GO:0015629 [actin cytoskeleton] GO:0042130 [negative regulation of T cell proliferation] GO:0048538 [thymus development] GO:0051301 [cell division] GO:0072686 [mitotic spindle] GO:0090235 [regulation of metaphase plate congression] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	718 aa 83.1 kDa	No	0
MAD1L1-004 ENSP00000395457 ENST00000429779	C9JJ38 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	157 aa 18.2 kDa	No	0
MAD1L1-005 ENSP00000390099 ENST00000455998	C9JIR0 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	144 aa 16.6 kDa	No	0
MAD1L1-006 ENSP00000413139 ENST00000429625	C9K086 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	213 aa 25.3 kDa	No	0
MAD1L1-007 ENSP00000401901 ENST00000445959	C9JTA2 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	205 aa 24.2 kDa	No	0
MAD1L1-013 ENSP00000393037 ENST00000444373	C9JX80 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	80 aa 9 kDa	No	0
MAD1L1-014 ENSP00000397417 ENST00000421113	C9J9H5 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	41 aa 4.7 kDa	No	0
MAD1L1-016 ENSP00000414877 ENST00000438959	C9JPS1 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007094 [mitotic spindle assembly checkpoint] Show all	199 aa 23.1 kDa	No	0
MAD1L1-017 ENSP00000394886 ENST00000450235	C9JP81 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007094 [mitotic spindle assembly checkpoint] GO:0015629 [actin cytoskeleton] Show all	266 aa 30.6 kDa	No	0
MAD1L1-018 ENSP00000394069 ENST00000437877	C9JKI7 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007094 [mitotic spindle assembly checkpoint] GO:0015629 [actin cytoskeleton] Show all	122 aa 13.9 kDa	No	0
MAD1L1-201 ENSP00000265854 ENST00000265854	Q9Y6D9 [Direct mapping] Mitotic spindle assembly checkpoint protein MAD1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007264 [small GTPase mediated signal transduction] GO:0015629 [actin cytoskeleton] GO:0051301 [cell division] GO:0072686 [mitotic spindle] GO:0090235 [regulation of metaphase plate congression] Show all	718 aa 83.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.