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CASP10

CANCER ATLAS

Gene description

 Caspase 10, apoptosis-related cysteine peptidase

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017059
CAB003780

GENE INFORMATION

Gene name

 CASP10 (HGNC Symbol)

Synonyms

 MCH4

Description

 Caspase 10, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 201182881 - 201229406

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000003400 (version 83.38)

Entrez gene

 843

UniProt

 Q92851 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92851

Antibodypedia

 CASP10 antibodies

PROTEIN BROWSER
CASP10-001
CASP10-002
CASP10-003
CASP10-007
CASP10-009
CASP10-010
CASP10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP10-001
ENSP00000286186
ENST00000286186
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008234 [cysteine-type peptidase activity]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 522 aa
59 kDa 		No 0
CASP10-002
ENSP00000272879
ENST00000272879
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008234 [cysteine-type peptidase activity]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 521 aa
59 kDa 		No 0
CASP10-003
ENSP00000237865
ENST00000346817
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008234 [cysteine-type peptidase activity]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 479 aa
54.6 kDa 		No 0
CASP10-007
ENSP00000363781
ENST00000374650
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 247 aa
28.4 kDa 		No 0
CASP10-009
ENSP00000314599
ENST00000313728
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008234 [cysteine-type peptidase activity]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 455 aa
51.8 kDa 		No 0
CASP10-010
ENSP00000396835
ENST00000448480
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008234 [cysteine-type peptidase activity]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 478 aa
54.5 kDa 		No 0
CASP10-201
ENSP00000353250
ENST00000360132
Q92851 [Direct mapping]
Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035877 [death effector domain binding]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0097190 [apoptotic signaling pathway]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097342 [ripoptosome]
Show all
 273 aa
31.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.