Cell atlas - CASP10 - The Human Protein Atlas

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CASP10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	CASP10
Gene description	Caspase 10, apoptosis-related cysteine peptidase
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain)
Additional location	In addition localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA017059
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to vesicles.

Main location

Golgi apparatus (uncertain)

Additional location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017059	A-431	Golgi apparatus
	HPA017059	A-431	Vesicles
	HPA017059	Hep G2	Golgi apparatus
	HPA017059	U-2 OS	Golgi apparatus
	HPA017059	U-2 OS	Vesicles

GENE INFORMATION
Gene name	CASP10 (HGNC Symbol)
Synonyms	MCH4
Description	Caspase 10, apoptosis-related cysteine peptidase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	201182881 - 201229406
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000003400 (version 83.38)
Entrez gene	843
UniProt	Q92851 (UniProt - Evidence at protein level)
neXtProt	NX_Q92851
Antibodypedia	CASP10 antibodies

PROTEIN BROWSER

CASP10-001	CASP10-002	CASP10-003	CASP10-007	CASP10-009	CASP10-010	CASP10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASP10-001 ENSP00000286186 ENST00000286186	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008234 [cysteine-type peptidase activity] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	522 aa 59 kDa	No	0
CASP10-002 ENSP00000272879 ENST00000272879	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008234 [cysteine-type peptidase activity] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	521 aa 59 kDa	No	0
CASP10-003 ENSP00000237865 ENST00000346817	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008234 [cysteine-type peptidase activity] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	479 aa 54.6 kDa	No	0
CASP10-007 ENSP00000363781 ENST00000374650	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	247 aa 28.4 kDa	No	0
CASP10-009 ENSP00000314599 ENST00000313728	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008234 [cysteine-type peptidase activity] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	455 aa 51.8 kDa	No	0
CASP10-010 ENSP00000396835 ENST00000448480	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008234 [cysteine-type peptidase activity] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	478 aa 54.5 kDa	No	0
CASP10-201 ENSP00000353250 ENST00000360132	Q92851 [Direct mapping] Caspase-10 Caspase-10 subunit p23/17 Caspase-10 subunit p12 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0035877 [death effector domain binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0097190 [apoptotic signaling pathway] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] Show all	273 aa 31.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.