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FKBP4

GENERAL INFORMATION

Gene name

 FKBP4

Gene description

 FK506 binding protein 4, 59kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA006148 , CAB017441
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FKBP4 (HGNC Symbol)

Synonyms

 FKBP52, FKBP59

Description

 FK506 binding protein 4, 59kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 2794953 - 2805423

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004478 (version 83.38)

Entrez gene

 2288

UniProt

 Q02790 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02790

Antibodypedia

 FKBP4 antibodies

PROTEIN BROWSER
FKBP4-001
FKBP4-004
FKBP4-006
FKBP4-007
FKBP4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP4-001
ENSP00000001008
ENST00000001008
Q02790 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006463 [steroid hormone receptor complex assembly]
GO:0006825 [copper ion transport]
GO:0007566 [embryo implantation]
GO:0010977 [negative regulation of neuron projection development]
GO:0030521 [androgen receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0030850 [prostate gland development]
GO:0031072 [heat shock protein binding]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031503 [protein complex localization]
GO:0032767 [copper-dependent protein binding]
GO:0034605 [cellular response to heat]
GO:0035259 [glucocorticoid receptor binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0044295 [axonal growth cone]
GO:0044822 [poly(A) RNA binding]
GO:0046661 [male sex differentiation]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048608 [reproductive structure development]
GO:0051219 [phosphoprotein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
GO:1900034 [regulation of cellular response to heat]
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 459 aa
51.8 kDa 		No 0
FKBP4-004
ENSP00000446368
ENST00000538622
F5H1U3 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0031072 [heat shock protein binding]
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 86 aa
9.5 kDa 		No 0
FKBP4-006
ENSP00000438491
ENST00000539181
H0YFG2 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0031072 [heat shock protein binding]
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 84 aa
9.5 kDa 		No 0
FKBP4-007
ENSP00000442193
ENST00000544366
H0YG86 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
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 23 aa
2.5 kDa 		No 0
FKBP4-201
ENSP00000486800
ENST00000630279
F5H120 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
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 51 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.