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ARHGAP33

GENERAL INFORMATION

Gene name

 ARHGAP33

Gene description

 Rho GTPase activating protein 33

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA030117 , HPA030118
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 ARHGAP33 (HGNC Symbol)

Synonyms

 FLJ39019, SNX26, TCGAP

Description

 Rho GTPase activating protein 33 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 35774532 - 35788822

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004777 (version 83.38)

Entrez gene

 115703

UniProt

 O14559 (UniProt - Evidence at protein level)

neXtProt

 NX_O14559

Antibodypedia

 ARHGAP33 antibodies

PROTEIN BROWSER
ARHGAP33-001
ARHGAP33-002
ARHGAP33-003
ARHGAP33-009
ARHGAP33-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP33-001
ENSP00000368227
ENST00000378944
O14559 [Direct mapping]
Rho GTPase-activating protein 33
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0035091 [phosphatidylinositol binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 1123 aa
119.8 kDa 		No 0
ARHGAP33-002
ENSP00000320038
ENST00000314737
O14559 [Direct mapping]
Rho GTPase-activating protein 33
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0035091 [phosphatidylinositol binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
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 1126 aa
121.1 kDa 		No 0
ARHGAP33-003
ENSP00000467844
ENST00000588248
K7EQI6 [Direct mapping]
Rho GTPase-activating protein 33
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Predicted intracellular proteins
Show all
GO:0007165 [signal transduction]
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 662 aa
69.6 kDa 		No 0
ARHGAP33-009
ENSP00000466443
ENST00000587447
K7EMC2 [Direct mapping]
Rho GTPase-activating protein 33
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Predicted intracellular proteins
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GO:0007165 [signal transduction]
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 863 aa
90.3 kDa 		No 0
ARHGAP33-201
ENSP00000007510
ENST00000007510
A0A0A0MQQ9 [Direct mapping]
Rho GTPase-activating protein 33
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Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0035091 [phosphatidylinositol binding]
Show all
 748 aa
81.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.