Tissue expression of ABCB5 - Summary - The Human Protein Atlas

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ABCB5

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABCB5
Gene description	ATP-binding cassette, sub-family B (MDR/TAP), member 5
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (epididymis)
GTEx:	Tissue enhanced (breast, adipose tissue)
FANTOM5:	Tissue enhanced (retina, epididymis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA026975
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (breast, adipose tissue)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, epididymis)

GENE INFORMATION
Gene name	ABCB5 (HGNC Symbol)
Synonyms	ABCB5alpha, ABCB5beta, EST422562
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 5 (HGNC Symbol)
Entrez gene summary	ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	p21.1
Chromosome location (bp)	20615207 - 20777038
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004846 (version 83.38)
Entrez gene	340273
UniProt	Q2M3G0 (UniProt - Evidence at protein level)
neXtProt	NX_Q2M3G0
Antibodypedia	ABCB5 antibodies

PROTEIN BROWSER

ABCB5-001	ABCB5-002	ABCB5-003	ABCB5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCB5-001 ENSP00000258738 ENST00000258738	Q2M3G0 [Direct mapping] ATP-binding cassette sub-family B member 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015562 [efflux transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030154 [cell differentiation] GO:0042391 [regulation of membrane potential] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0048058 [compound eye corneal lens development] GO:0055085 [transmembrane transport] Show all	812 aa 89.8 kDa	No	5
ABCB5-002 ENSP00000383899 ENST00000406935	Q2M3G0 [Direct mapping] ATP-binding cassette sub-family B member 5 Show all	Transporters Primary Active Transporters Predicted intracellular proteins Show all	GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008152 [metabolic process] GO:0015562 [efflux transmembrane transporter activity] GO:0016887 [ATPase activity] GO:0030154 [cell differentiation] GO:0042391 [regulation of membrane potential] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0048058 [compound eye corneal lens development] GO:0055085 [transmembrane transport] Show all	126 aa 14.1 kDa	No	0
ABCB5-003 ENSP00000406730 ENST00000443026	Q2M3G0 [Direct mapping] ATP-binding cassette sub-family B member 5 A0A024RA03 [Target identity:100%; Query identity:100%] HCG38926, isoform CRA_a Show all	Transporters Primary Active Transporters Predicted intracellular proteins Show all	GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008152 [metabolic process] GO:0015562 [efflux transmembrane transporter activity] GO:0016887 [ATPase activity] GO:0030154 [cell differentiation] GO:0042391 [regulation of membrane potential] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0048058 [compound eye corneal lens development] GO:0055085 [transmembrane transport] Show all	131 aa 14.7 kDa	No	0
ABCB5-004 ENSP00000384881 ENST00000404938	Q2M3G0 [Direct mapping] ATP-binding cassette sub-family B member 5 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0015562 [efflux transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0030154 [cell differentiation] GO:0042391 [regulation of membrane potential] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0048058 [compound eye corneal lens development] GO:0055085 [transmembrane transport] Show all	1257 aa 138.6 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
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