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A majority of malignancies showed weak to moderate cytoplasmic staining. Hepatocellular carcinomas were strongly stained. Skin cancers were negative.
GENE INFORMATION
Gene name
SLC25A13 (HGNC Symbol)
Synonyms
ARALAR2, CITRIN, CTLN2
Description
Solute carrier family 25 (aspartate/glutamate carrier), member 13 (HGNC Symbol)
Entrez gene summary
This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Q9UJS0 [Direct mapping] Calcium-binding mitochondrial carrier protein Aralar2
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Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q9UJS0 [Direct mapping] Calcium-binding mitochondrial carrier protein Aralar2
Show all
Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
