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SLC25A13

GENERAL INFORMATION

Gene name

 SLC25A13

Gene description

 Solute carrier family 25 (aspartate/glutamate carrier), member 13

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018997
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC25A13 (HGNC Symbol)

Synonyms

 ARALAR2, CITRIN, CTLN2

Description

 Solute carrier family 25 (aspartate/glutamate carrier), member 13 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 96120220 - 96322147

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000004864 (version 83.38)

Entrez gene

 10165

UniProt

 Q9UJS0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJS0

Antibodypedia

 SLC25A13 antibodies

PROTEIN BROWSER
SLC25A13-001
SLC25A13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC25A13-001
ENSP00000265631
ENST00000265631
Q9UJS0 [Direct mapping]
Calcium-binding mitochondrial carrier protein Aralar2
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Transporters
   Electrochemical Potential-driven transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006754 [ATP biosynthetic process]
GO:0006810 [transport]
GO:0015183 [L-aspartate transmembrane transporter activity]
GO:0015810 [aspartate transport]
GO:0015813 [L-glutamate transport]
GO:0043490 [malate-aspartate shuttle]
GO:0044281 [small molecule metabolic process]
GO:0045333 [cellular respiration]
GO:0051592 [response to calcium ion]
GO:0089711 [L-glutamate transmembrane transport]
GO:0089712 [L-aspartate transmembrane transport]
Show all
 675 aa
74.2 kDa 		No 0
SLC25A13-201
ENSP00000400101
ENST00000416240
Q9UJS0 [Direct mapping]
Calcium-binding mitochondrial carrier protein Aralar2
Show all
Transporters
   Electrochemical Potential-driven transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006754 [ATP biosynthetic process]
GO:0006810 [transport]
GO:0015183 [L-aspartate transmembrane transporter activity]
GO:0015810 [aspartate transport]
GO:0015813 [L-glutamate transport]
GO:0043490 [malate-aspartate shuttle]
GO:0044281 [small molecule metabolic process]
GO:0045333 [cellular respiration]
GO:0051592 [response to calcium ion]
GO:0089711 [L-glutamate transmembrane transport]
GO:0089712 [L-aspartate transmembrane transport]
Show all
 676 aa
74.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.