Expression of HCCS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Holocytochrome c synthase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA002946

GENE INFORMATION
Gene name	HCCS (HGNC Symbol)
Synonyms	CCHL, MLS
Description	Holocytochrome c synthase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	11111301 - 11123078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004961 (version 83.38)
Entrez gene	3052
UniProt	P53701 (UniProt - Evidence at protein level)
neXtProt	NX_P53701
Antibodypedia	HCCS antibodies

PROTEIN BROWSER

HCCS-001	HCCS-002	HCCS-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCCS-001 ENSP00000326579 ENST00000321143	P53701 [Direct mapping] Cytochrome c-type heme lyase A0A024RBY9 [Target identity:100%; Query identity:100%] Holocytochrome c synthase (Cytochrome c heme-lyase), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004408 [holocytochrome-c synthase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0009887 [organ morphogenesis] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	268 aa 30.6 kDa	Yes	0
HCCS-002 ENSP00000370139 ENST00000380762	P53701 [Direct mapping] Cytochrome c-type heme lyase A0A024RBY9 [Target identity:100%; Query identity:100%] Holocytochrome c synthase (Cytochrome c heme-lyase), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004408 [holocytochrome-c synthase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0009887 [organ morphogenesis] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	268 aa 30.6 kDa	Yes	0
HCCS-003 ENSP00000370140 ENST00000380763	P53701 [Direct mapping] Cytochrome c-type heme lyase A0A024RBY9 [Target identity:100%; Query identity:100%] Holocytochrome c synthase (Cytochrome c heme-lyase), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004408 [holocytochrome-c synthase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0009887 [organ morphogenesis] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	268 aa 30.6 kDa	Yes	0