Expression of SLC25A5 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

Protein class

FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA071684

GENE INFORMATION
Gene name	SLC25A5 (HGNC Symbol)
Synonyms	2F1, ANT2, T2, T3
Description	Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	119468400 - 119471319
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000005022 (version 83.38)
Entrez gene	292
UniProt	P05141 (UniProt - Evidence at protein level)
neXtProt	NX_P05141
Antibodypedia	SLC25A5 antibodies

PROTEIN BROWSER

SLC25A5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A5-001 ENSP00000360671 ENST00000317881	P05141 [Direct mapping] ADP/ATP translocase 2 ADP/ATP translocase 2, N-terminally processed Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005887 [integral component of plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006810 [transport] GO:0007059 [chromosome segregation] GO:0008284 [positive regulation of cell proliferation] GO:0015207 [adenine transmembrane transporter activity] GO:0015853 [adenine transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0031625 [ubiquitin protein ligase binding] GO:0042645 [mitochondrial nucleoid] GO:0043209 [myelin sheath] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071817 [MMXD complex] GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] Show all	298 aa 32.9 kDa	No	3