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SLC25A5

GENERAL INFORMATION

Gene name

 SLC25A5

Gene description

 Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

Protein class

 FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA071684
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC25A5 (HGNC Symbol)

Synonyms

 2F1, ANT2, T2, T3

Description

 Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 119468400 - 119471319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005022 (version 83.38)

Entrez gene

 292

UniProt

 P05141 (UniProt - Evidence at protein level)

neXtProt

 NX_P05141

Antibodypedia

 SLC25A5 antibodies

PROTEIN BROWSER
SLC25A5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC25A5-001
ENSP00000360671
ENST00000317881
P05141 [Direct mapping]
ADP/ATP translocase 2 ADP/ATP translocase 2, N-terminally processed
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006810 [transport]
GO:0007059 [chromosome segregation]
GO:0008284 [positive regulation of cell proliferation]
GO:0015207 [adenine transmembrane transporter activity]
GO:0015853 [adenine transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0042645 [mitochondrial nucleoid]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071817 [MMXD complex]
GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
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 298 aa
32.9 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.