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Several cases of cancer tissues, melanomas, colorectal, breast, prostate, ovarian, testicular urothelial, gastric and pancreatic cancers showed weak to moderate cytoplasmic positivity. Remaining cancer tissues were in general negative.
Testicular cancers showed moderate cytoplasmic staining. Several endometrial, ovarian, cervical, breast and pancreatic cancers showed moderate cytoplasmic and/or nuclear staining. Remaining cancer tissues were in general weakly stained or negative.
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]