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A majority of cancers were negative or weakly stained. Several colorectal, urothelial, renal and liver cancers showed moderate cytoplasmic and nucleolar staining.
Prostate cancer as well as several breast, urothelial, renal, pancreatic and liver cancers showed moderate cytoplasmic staining. Most of the remaining cancers were weakly stained or negative.
A majority of malignant cells displayed moderate cytoplasmic immunoreactivity. A few cases of colorectal, liver, prostate and stomach cancers exhibited strong positivity. Most renal, endometrial and lung cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CROT (HGNC Symbol)
Synonyms
COT
Description
Carnitine O-octanoyltransferase (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Enzymes ENZYME proteins Transferases Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Transporters SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
