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CROT

GENERAL INFORMATION

Gene name

 CROT

Gene description

 Carnitine O-octanoyltransferase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, high abundance in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA019052 , HPA019364 , HPA019365
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CROT (HGNC Symbol)

Synonyms

 COT

Description

 Carnitine O-octanoyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

Chromosome

 7

Cytoband

 q21.12

Chromosome location (bp)

 87345681 - 87399795

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000005469 (version 83.38)

Entrez gene

 54677

UniProt

 Q9UKG9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKG9

Antibodypedia

 CROT antibodies

PROTEIN BROWSER
CROT-001
CROT-002
CROT-003
CROT-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CROT-001
ENSP00000331981
ENST00000331536
Q9UKG9 [Direct mapping]
Peroxisomal carnitine O-octanoyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008458 [carnitine O-octanoyltransferase activity]
GO:0009437 [carnitine metabolic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051791 [medium-chain fatty acid metabolic process]
Show all
 612 aa
70.2 kDa 		No 0
CROT-002
ENSP00000413575
ENST00000419147
Q9UKG9 [Direct mapping]
Peroxisomal carnitine O-octanoyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Transporters
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008458 [carnitine O-octanoyltransferase activity]
GO:0009437 [carnitine metabolic process]
GO:0010243 [response to organonitrogen compound]
GO:0015908 [fatty acid transport]
GO:0015936 [coenzyme A metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051791 [medium-chain fatty acid metabolic process]
Show all
 640 aa
73.4 kDa 		No 0
CROT-003
ENSP00000404867
ENST00000412227
Q9UKG9 [Direct mapping]
Peroxisomal carnitine O-octanoyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0008458 [carnitine O-octanoyltransferase activity]
GO:0009437 [carnitine metabolic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051791 [medium-chain fatty acid metabolic process]
Show all
 87 aa
10.2 kDa 		No 0
CROT-004
ENSP00000411983
ENST00000442291
C9J3D7 [Direct mapping]
Peroxisomal carnitine O-octanoyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 574 aa
65.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.